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Background
Highly immunized patients are a challenge for organ transplantation programs. One way of increasing the likelihood of transplantation in this group of patients is to expand the possible donations by defining acceptable HLA mismatches. In the Scandiatransplant Acceptable Mismatch Program (STAMP), a de‐centralized approach has been implemented in 2009.
Aims
The program has been improved...
Recent years have seen a rapid increase in the discovery of novel allelic variants of the human leukocyte antigen (HLA) genes. Commonly, only the exons encoding the peptide binding domains of novel HLA alleles are submitted. As a result, the IPD‐IMGT/HLA Database lacks sequence information outside those regions for the majority of known alleles. This has implications for the application of the new...
Transplantation of an human leukocyte antigen (HLA) mismatched graft can lead to the development of donor‐specific antibodies (DSA), which can result in antibody mediated rejection and graft loss as well as complicate repeat transplantation. These DSA are induced by foreign epitopes present on the mismatched HLA antigens of the donor. However, not all epitopes appear to be equally effective in their...
Antibody identification by a bead array assay in a kidney patient revealed several HLA‐specific antibodies including one directed against the HLA‐B7 antigen. Low‐resolution typing of the patient indicated the presence of an
HLA‐B*07 allele. To rule out an HLA‐specific autoantibody the HLA‐typing of the patient was further refined by nucleotide sequencing on a next‐generation sequencing platform and...
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